Suspected Metformin-induced Cobalamin Deficiency Mimicking Thrombotic Thrombocytopenic Purpura
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چکیده
منابع مشابه
Severe vitamin B12 deficiency mimicking thrombotic thrombocytopenic purpura.
A previously healthy 43-year-old man with chronic alcoholism presented to a rural medical center with a 2-week history of confusion, fever, dyspnea, dizziness, and fatigue associated with diarrhea and hematochezia. Laboratory results were notable for a platelet count of 19 3 10/L, hemoglobin of 5.0 g/dL, hematocrit of 15.1%, white blood cell count of 3.2 3 10/L, a reticulocyte count of 5.9%, me...
متن کاملMetastatic prostate cancer mimicking thrombotic thrombocytopenic purpura.
A 47-year-old African American man presented with lightheadedness and exertional dyspnea. Laboratory work revealed: hemoglobin, 2.9 g/dL; platelets, 17 3 10/L; and lactate dehydrogenase, 1492 IU/L. Folate, B12, and coagulation studies were normal. His peripheral smear showed increased schistocytes, polychromasia, and nucleated red blood cells. The patient was started on plasma exchange for pres...
متن کاملDeficiency of ADAMTS13 and thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura, characterized by the presence of systemic hyaline thrombi in the arterioles and capillaries, is a potentially fatal disease that responds to plasma infusion or exchange. Recent studies have demonstrated that a metalloprotease in the normal plasma cleaves endothelial von Willebrand factor to a series of multimers. A deficiency of the protease, due to autoimmu...
متن کاملDeficiency of ADAMTS13 Causes Thrombotic Thrombocytopenic Purpura
In the circulation, a plasma metalloprotease, ADAMTS13, cleaves von Willebrand factor (vWF) in a shear-dependent manner. This article reviews the role of this cleavage in regulating VWF-platelet interaction and proposes a scheme for understanding how a deficiency of ADAMTS13 results in the development of microthrombi in patients with thrombotic thrombocytopenic purpura. (Arterioscler Thromb Vas...
متن کاملInherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report
BACKGROUND Thrombotic thrombocytopenic purpura is a very rare hereditary blood deficiency disorder of ADAMTS13 (von Willebrand factor-cleaving protease) and a life-threatening thrombotic microangiopathy characterized by thrombocytopenia and microangiopathic hemolytic anemia. The deficiency in ADAMTS13 metalloprotease, which cleaves the von Willebrand factor, may be congenital or acquired. The c...
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ژورنال
عنوان ژورنال: Cureus
سال: 2020
ISSN: 2168-8184
DOI: 10.7759/cureus.6921